Piperidine → HCID 11352433, compound

Participants

Reaction Steps

Treatment of compound 32 with piperidine as described in Example 19 (Step 2) afforded the title compound, 33, as a light yellow solid (85 mg, 77%). 1HNMR (400 MHz, DMSO-d6): δ 0.85 (t, 3H), 1.35 (br, 2H), 1.74 (br, 4H), 2.40 (q, 2H), 3.00 (br, 2H), 3.44 (br, 2H), 4.36 (br, 2H), 6.51 (d, J=16.1 Hz, 1H), 6.87-6.90 (m, 4H), 7.09-7.19 (m, 5H), 7.25 (d, J=8.1 Hz, 2H), 7.58 (d, J=16.1 Hz, 1H), 7.70 (d, J=8.2 Hz, 2H), 10.17 (br, 1H), 12.39 (br, 1H); MS m/z 496 (M+H)+; Anal. calculated for C32H33N1O4.HCl.1.5H2O: C, 68.74; H, 6.67; N, 2.50; Found: C, 68.31; H, 6.34; N, 2.37.

Provenance & Evidence