Pyridine → HCID 178476335, compound

Participants

Reaction Steps

A solution of 27.9 g (86.7 mmol) of trans-[2-(4-hydroxymethyl-cyclohexyl)-ethyl]-carbamic acid tert-butyl ester, 41 mL (434 mmol, 5 eq) of acetic anhydride and 35 mL (434 mmol, 5 eq) of pyridine in 140 mL of CH2Cl2 was stirred at RT for 16 h. The reaction mixture was then taken up in ether and washed with 1M HCl solution, sodium hydrogen carbonate solution and water. Then, the ether-phase was dried over MgSO4 and concentrated to yield 26.0 g crude trans-acetic acid 4-(2-tert-butoxycarbonylamino-ethyl)-cyclohexylmethyl ester as colorless viscous oil, MS: 200 [(M-(tert-butoxycarbonyl))H+].

Provenance & Evidence