Diisopropylethylamine → HCID 178483655, compound

Participants

Reaction Steps

A solution of 0.250 g (1.13 mmol) of trans-4-(2-methylamino-ethyl)-cyclohexanecarboxylic acid•HCl, 1.04 mL (6.09 mmol, 5.3 eq) of Huenig's base and 0.412 g (2.26 mmol, 2 eq) of 2-chloro-4-(trifluoromethyl)pyrimidine in 4 mL of DMA were reacted at RT for 19 h. The solvent was evaporated and the residue partitioned between Et2O (×3)/aqueous 10% KH2PO4, dried over Na2SO4, and evaporated to yield 0.422 g (quantitative) of trans-4-{2-[methyl-(4-trifluoromethyl-pyrimidin-2-yl)-amino]-ethyl}-cyclohexanecarboxylic acid, MS: 330 (M−H−), MP: 110-112° C.

Provenance & Evidence