Methanol → HCID 178501119, compound

Participants

Reaction Steps

At −10° C., 2.17 mL (3.57 g, 30 mmol, 3 eq) of thionyl chloride were added to a cooled suspension of 1.57 g (10 mmol) of trans-4-aminomethyl-cyclohexanecarboxylic acid in 20 mL of MeOH. Subsequently the mixture was stirred at RT for 18 h. The solvent was then removed at normal pressure to give 2.07 g (quantitative) of trans-4-aminomethyl-cyclohexanecarboxylic acid methyl ester-hydrochloride as white crystals, MS: 171 (M).

Provenance & Evidence