Toluene → HCID 178500456, compound

Participants

Reaction Steps

2 g (5.5 mmol) of trans-N-(4-formyl-cyclohexylmethyl)-N-methyl-4-trifluoromethyl-benzenesulfonamide and 2.2 g (6.6 mmol, 1.2 eq) of methyl (triphenyl-phosphoranylidene)acetate in 25 mL of toluene were stirred at 90° C. for 1 h. The solution was concentrated and chromatographed on silicagel with CH2Cl2:Et2O 95:5 as eluent, giving 2.09 g (91%) of trans-3-(4-{[methyl-(4-trifluoromethyl-benzenesulfonyl)-amino]-methyl}-cyclohexyl)-acrylic acid methyl ester as an off white solid which was a mixture of E and Z isomers (98:2), MS: 437 (M+NH4+).

Provenance & Evidence