HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzylamine → Ammonia
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | 5-(2R)-2-Oxiranyl-8-(phenylmethoxy)-2(1H)-quinolinone | HCID 11437812 | — |
| Product | Ammonia | HCID 222 | — |
| Product | 5-[(1R)-2-(Benzylamino)-1-hydroxyethyl]-8-(benzyloxy)quinolin-2(1H)-one | HCID 69119720 | — |
Reaction Steps
8-(Benzyloxy)-5-[(2R)-oxiran-2-yl]quinolin-2(1H)-one (0.102 g) (WO 9525104), was dissolved in benzylamine (0.5 ml) and heated in a microwave oven for 15 min at 150°. Excess benzylamine was removed by evaporation on a rotary evaporator and the residue was purified on a silica SPE bond elut cartridge using MeOH/DCM-0.880 ammonia mixtures, to give the title compound (106 mg). LCMS RT=2.30 min
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07442839B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-880ac37b3955411491cae66a6889f58c |
| Source note | uspto-grants-2008_10 |