p-Chlorobenzenesulfonic acid → HCID 131727139, compound

Participants

Reaction Steps

4-Chlorobenzene sulfonic acid (19 mg) was added to a solution of 4-{(1R)-2-[(6-{4-[3-(cyclopentylsulfonyl)phenyl]butoxy}hexyl)amino]-1-hydroxyethyl}-2-(hydroxymethyl)phenol (55 mg) (dissolved by gentle warming) in propan-2-ol (0.5 ml) at 21°. After a few minutes crystals had separated out. These were collected, and rinsed with propan-2-ol to give crystals of the title compound, δ (DMSO-d6) 9.40 (1H,s), 8.42 (2H, br s), 7.72-7.67 (2H, m), 7.62-7.55 (4H, m), 7.38 (2H, m), 7.32 (1H, d, J=2 Hz), 7.05 (1H, dd, J 2,8 Hz), 6.75 (1H, d, J=8 Hz), 5.97 (1H, br s), 5.00 (1H, v br s), 4.76 (1H, br d, J=9 Hz), 4.49 (2H, s), 3.75 (1H m), 3.32 (4H, partially obscured t), 3.10-2.87 (4H, 2m), 2.71 (2H, t, J=7 Hz), 1.90-1.25 (20H, m).

Provenance & Evidence