Sodium ethoxide → 2-(4-Methylpyridin-2-yl)-5-(propan-2-yl)cyclohexane-1,3-dione

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Reaction Steps

The procedure of Example 2 was used to prepare the title compound from ethyl 3-(1-methylethyl)-6-(4-methyl-2-pyridinyl)-5-oxohexanoate and sodium ethoxide using a 2 hour reflux period in ethanol. The product was liberated as an oil from the aqueous phase by adjusting the pH to about 5 and recovered by ether extraction. The ether extract was worked up giving a semi-solid which was recrystallized successively from ethyl acetate and isopropyl ether giving the product as a solid, mp 104.5°-106.5° C. The confirmatory elemental analysis is shown in Table II.

Provenance & Evidence