HCID 53851186, compound → HCID 54249876, compound

HRID 2118460Notes

Reaction equation

HRID 2118460 reaction equation
[CH3:1][C:2]1([CH3:26])[CH2:6][CH2:5][C:4]([CH3:8])([CH3:7])[CH:3]1[NH:9][C:10](=[O:25])[C:11]([NH:14]C(OCC1C=CC=CC=1)=O)([CH3:13])[CH3:12]>CO.[Pd]>[CH3:1][C:2]1([CH3:26])[CH2:6][CH2:5][C:4]([CH3:7])([CH3:8])[CH:3]1[NH:9][C:10](=[O:25])[C:11]([NH2:14])([CH3:13])[CH3:12]

Participants

4

Reactant 1

HCID 53851186HCID 53851186, compound

Product 1

HCID 54249876HCID 54249876, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

N-Cbz-2-aminoisobutyric acid 2,2,5,5-tetramethylcyclopentyl amide is dissolved in CH3OH and is hydrogenated over 5% Pd/C in a Parr hydrogenation apparatus. When the reaction is complete the mixture is filtered through Celite and concentrated to yield 2-aminoisobutyric acid 2,2,5,5-tetramethylcyclopentyl amide.

Workup

  1. filtrationis filtered through Celite
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-32a3da75e8b142cbbd4a66ea53d60196
Source dataset
uspto-grants-1987_07
Patent number
US04678674

Reaction notes

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