HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2118472Generated: November 4, 2026
Sodium Chloride → (1-Formylcyclopropyl)carbamic acid tert-butyl ester
https://huagongshe.com/reaction/2118472
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Chloride | HCID 5234 | — |
| Reactant | Hydride | HCID 166653 | — |
| Reactant | 1-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid | HCID 688396 | — |
| Reactant | Bis(1-methylpiperazin-2-yl)alumanylium;hydride | HCID 18792082 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | (1-Formylcyclopropyl)carbamic acid tert-butyl ester | HCID 10352385 | — |
Reaction Steps
N-Boc-1-amino-1-cyclopropanecarboxylic acid is dissolved in tetrahydrofuran and stirred at 0° C. under argon. Bis(N-methylpiperazinyl)aluminum hydride is added and the reaction mixture is heated to reflux overnight. Ether is then added, and the excess hydride is quenced with saturated NaCl. The aqueous phase is separated and extracted with ether. The combined organic phases are washed with 2M NaOH, 2M HCl and saturated NaCl. The solution is dried over Na2SO4 and evaporated to yield N-Boc-1-amino-1-cyclopropanecarboxaldehyde.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04678675 |
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| Source dataset | uspto-grants-1987_07 |
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| ORD ID | ord-63e34411b3ea4a11b39e763a8fadaea1 |
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| Source note | uspto-grants-1987_07 |
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