1-Phenylpiperazine → 7-[4-(4-Phenyl-1-piperazinyl)butoxy]-4H-1-benzopyran-4-one

HRID 2118488Notes

Reaction equation

HRID 2118488 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]1[CH:17]=[CH:16][C:10]2[C:11](=[O:15])[CH:12]=[CH:13][O:14][C:9]=2[CH:8]=1.[C:18]1([N:24]2[CH2:29][CH2:28][NH:27][CH2:26][CH2:25]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>O>[C:18]1([N:24]2[CH2:29][CH2:28][N:27]([CH2:2][CH2:3][CH2:4][CH2:5][O:6][C:7]3[CH:17]=[CH:16][C:10]4[C:11](=[O:15])[CH:12]=[CH:13][O:14][C:9]=4[CH:8]=3)[CH2:26][CH2:25]2)[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

4

Reactant 2

HCID 70961-PhenylpiperazineHCID 139239677-(4-Chlorobutoxy)-4H-1-benzopyran-4-one

Product 1

HCID 139239857-[4-(4-Phenyl-1-piperazinyl)butoxy]-4H-1-benzopyran-4-one

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound was prepared by the method described above in Examples 1-3. Thus, 7-(4-chlorobutoxy)-4H-1-benzopyran-4-one, as prepared above in Preparation 2, (3.79 g, 15 mmol) was treated with 1-phenylpiperazine (2.59 g; 16 mmol) in the usual way, yielding 3.76 g of 7-[4-(4-phenyl-1-piperazinyl)butoxy-]4H-1-benzopan-4-one.1.5 HCL (H2O), mp 204°-206° C.

Sources & evidence

ORD record
ord-a85370b7c7b14e52b8e297db2b345759
Source dataset
uspto-grants-1987_07
Patent number
US04678787

Reaction notes

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