Hydrochloric Acid → Fasudil Hydrochloride

Participants

Reaction Steps

5 g of 1-(5-isoquinolinesulfonyl)homopiperazine (Compound(1)) as prepared in substantially the same manner as in Example 3 was dissolved in 40 ml of methanol, and the pH of the solution was adjusted to 6 with 1N hydrochloric acid. Then the solution was condensed under reduced pressure to obtain a crystalline residue. The crystalline residue thus obtained was recrystallized from methanol-ether to obtain 1-(5isoquinolinesulfonyl)homopiperazine hydrochloride. Analytical data on this compound are given below.

Provenance & Evidence