HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloral Hydrate → N-[2-(3,4-dimethoxyphenyl)ethyl]formamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloral Hydrate | HCID 2707 | — |
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Homoveratrylamine | HCID 8421 | — |
| Solvent | Water | HCID 962 | — |
| Product | N-[2-(3,4-dimethoxyphenyl)ethyl]formamide | HCID 84337 | — |
Reaction Conditions
| Temperature | 120 °C |
|---|
Reaction Steps
First, 2-(3,4-dimethoxyphenyl)-ethylamine (181.2 g, 1 mol) and chloral hydrate (181 g, 1.1 mol) are mixed together and heated to 120° C., with stirring, for 20 minutes and any volatile components (chloroform and water) are eliminated in a water jet vacuum at an oil bath temperature of 140° C. An oil is left behind which is further processed without any purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04678792 |
| Source dataset | uspto-grants-1987_07 |
| ORD ID | ord-e687a79b375e40ad8ca7776ad80c5a88 |
| Source note | uspto-grants-1987_07 |