Sulfuric Acid → HCID 13562947, compound

Participants

Reaction Steps

N-Formyl-N(2-chlorobenzyl)-2(3,4-dimethoxyphenyl)-ethylamine (12.1 g) are dissolved in toluene (50 ml), combined with phosphorus oxychloride (15.2 g=9 ml) and heated under reflux for 1.5 hours. The mixture is concentrated, the residue is mixed with ice, made alkaline with potassium carbonate and extracted with ethyl acetate. The ethyl acetate extract is concentrated by evaporation. The residue obtained is dissolved in isopropanol and mixed with conc. sulphuric acid (2 ml). After cooling, the mixture is suction filtered, washed with isopropanol and ether and dried. Yield: 8.6 g. Melting point: 226°-228° C.

Provenance & Evidence