Dibenzylhydroxylamine → N-Cyclohexyl-3-[(N,N-dibenzylamino)oxy]pyrrolidine-2,5-dione

HRID 2118564Notes

Reaction equation

HRID 2118564 reaction equation
[CH2:1]([N:8]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[OH:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH:17]1([N:23]2[C:27](=[O:28])[CH:26]=[CH:25][C:24]2=[O:29])[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1>>[CH:17]1([N:23]2[C:27](=[O:28])[CH2:26][CH:25]([O:9][N:8]([CH2:1][C:2]3[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=3)[CH2:10][C:11]3[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=3)[C:24]2=[O:29])[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22]1

Participants

3

Reactant 2

HCID 69297DibenzylhydroxylamineHCID 742031H-Pyrrole-2,5-dione, 1-cyclohexyl-

Product 1

HCID 14224082N-Cyclohexyl-3-[(N,N-dibenzylamino)oxy]pyrrolidine-2,5-dioneYield 61.1%

Procedure

The procedure of Example 1 is repeated using 5.33 g (25 mmole) of N,N-dibenzylhydroxylamine and 4.48 g (25 mmole) of N-cyclohexylmaleimide. The residue was crystallized from ethanol to give 6.0 g (61%) of a white solid, mp 75°-77° C.

Workup

  1. customThe residue was crystallized from ethanol

Sources & evidence

ORD record
ord-ef41b32bc39f42bebc8eca07ac2ef61a
Source dataset
uspto-grants-1987_07
Patent number
US04678826

Reaction notes

Loading…