反应详情

The starting material may be prepared as follows: Reaction of 4-methylthiopyridine with 5 equivalents of chloroacetone at 40°-50° for 18 hours gave 1-acetylmethyl-4-methylthiopyridinium chloride. n.m.r. in solvent B: 2.27(s, 3H); 2.71(s, 3H); 6.0(s, 2H); 7.93(d, 2H); 8.5(d, 2H). Oxidation of this compound with a slight excess of metachlorpenbenzoic acid in CH2Cl2 /TFA at 0° to ambient temperature gave 1-acetylmethyl-4-methanesulphinyl pyridinium chloride. n.m.r. in solvent B: 2.32(s, 3H); 3.01(s, 3H); 5.84(s, 8.5(d, 2H); 9.0(d, 2H).

1. customThe starting material may be prepared