Tributylvinyltin → 7-Amino-4-vinylisoindolinone

Participants

Role	Name	HCID	Charge
Reactant	Tributylvinyltin	HCID 81998	—
Reactant	7-Amino-4-bromo-2,3-dihydroisoindol-1-one	HCID 19701932	—
Solvent	Tetrahydrofuran	HCID 8028	—
Product	7-Amino-4-vinylisoindolinone	HCID 68488659	68%

Reaction Steps

In a similar manner to Step 1 of Example 10, 7-amino-4-bromoisoindolinone (300 mg, 1.32 mmol) was dissolved in THF (12 mL), and the solution was treated with vinyltributyltin (1.16 mL, 3.96 mmol) and bis(o-toluoylphosphine)dichloropalladium (166 mg, 0.211 mmol), followed by purification by slurry using hexane and chloroform to obtain 7-amino-4-vinylisoindolinone (155 mg, yield 68%).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07745641B2
Source dataset	uspto-grants-2010_06
ORD ID	ord-dd23c3d5e843441b888f71abd7d17ffd
Source note	uspto-grants-2010_06