HCID 12884453, compound → HCID 88628981, compound

HRID 2118607Notes

Reaction equation

HRID 2118607 reaction equation
[C:1]([NH:20][C:21]1[S:22][CH:23]=[C:24](/[C:26](=[N:32]/[O:33][CH2:34][CH2:35]Br)/[C:27]([O:29]CC)=[O:28])[N:25]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[SH:37][C:38]1[CH:50]=[CH:49][CH:48]=[CH:47][C:39]=1[C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41]>>[C:1]([NH:20][C:21]1[S:22][CH:23]=[C:24](/[C:26](=[N:32]/[O:33][CH2:34][CH2:35][S:37][C:38]2[CH:50]=[CH:49][CH:48]=[CH:47][C:39]=2[C:40]([O:42][C:43]([CH3:46])([CH3:45])[CH3:44])=[O:41])/[C:27]([OH:29])=[O:28])[N:25]=1)([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)([C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

3

Reactant 2

HCID 12884453HCID 12884453, compoundHCID 20028970HCID 20028970, compound

Product 1

HCID 88628981HCID 88628981, compound

Procedure

The starting material may be prepared by reaction of ethyl 2-(2-tritylaminothiazol-4-yl)-2-((Z)-bromoethoxyimino)acetate (UK Patent Application No. 2017702) with t-butyl 2-mercaptobenzoate and hydrolysis of the resulting ester to give 2-(2-tritylaminothiazol-4-yl)-2-[(Z)-2-(2-t-butoxycarbonylphenylthio)ethoxyimino]acetic acid, n.m.r. in solvent C: 1.6(s, 9H); 3.3(t, 2H); 4.4(t, 2H); 6.67(s, 1H); 7.0-8.0(m, 4H); 7.34(s, 15H).

Sources & evidence

ORD record
ord-b25e417e0296416fb4c905d687c71d50
Source dataset
uspto-grants-1987_07
Patent number
US04678781

Reaction notes

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