HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 1-Bromo-5-nitroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Nitrate | HCID 24434 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 1-Bromoisoquinoline | HCID 640963 | — |
| Solvent | Sulfuric Acid | HCID 1118 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-Bromo-5-nitroisoquinoline | HCID 14617005 | — |
Reaction Steps
The starting material was prepared by reaction of 1-bromoisoquinoline in concentrated H2SO4 at 0° with KNO3. The reaction mixture was worked up with water, NaHCO3 and EtOAc to give 1-bromo-5-nitro isoquinoline, m.p. 187°-8°. Reaction of this compound with trimethyloxonium tetrafluoroborate in CH2Cl2 gave impure 1-bromo-2-methyl-5-nitroisoquinolinium tetrafluoroborate which was used as such. n.m.r in solvent A: 3.5(s, 3H); 7.7-8.7(m, 5H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04678781 |
| Source dataset | uspto-grants-1987_07 |
| ORD ID | ord-bfe9906dc12d4c22afc26da89b0bab9b |
| Source note | uspto-grants-1987_07 |