Methyl iodide → HCID 20028973, compound

HRID 2118613Notes

Reaction equation

HRID 2118613 reaction equation
[CH2:1]([C:4]1[N:13]=[C:12]([S:14][CH3:15])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=1)[CH2:2][CH3:3].[CH3:16][I:17]>>[I-:17].[CH3:16][N+:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:12]([S:14][CH3:15])=[N:13][C:4]=1[CH2:1][CH2:2][CH3:3]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 20028883HCID 20028883, compound

Product 1

HCID 20028973HCID 20028973, compound

Procedure

A solution of 2-propyl-4-methylthioquinazoline (1.08 g.) in methyl iodide (5 ml.) was heated under reflux for 18 hours. The solid was separated from the cooled mixture and washed with ether to give 1-methyl-4-methylthio-2-propylquinazolinium iodide; n.m.r. in d6DMSO: 1.15(t, 3H); 2.0(m, 2H); 2.9(s, 3H); 3.35(t, 2H); 4.3(s, 3H); 7.9-8.6(complex, 4H).

Workup

  1. temperatureunder reflux for 18 hours
  2. customThe solid was separated from the cooled mixture
  3. washwashed with ether

Sources & evidence

ORD record
ord-11e1d98bee394cbca99d4fb838e67262
Source dataset
uspto-grants-1987_07
Patent number
US04678781

Reaction notes

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