Isatoic Anhydride → 2-amino-N-(3-imidazol-1-ylpropyl)benzamide

HRID 2118647Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2118647
[C:1]12[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=1)[NH:6]C(=O)[O:4][C:2]2=O.[N:13]1([CH2:18][CH2:19][CH2:20][NH2:21])[CH:17]=[CH:16][N:15]=[CH:14]1>C1(C)C=CC=CC=1>[NH2:6][C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][C:1]=1[C:2]([NH:21][CH2:20][CH2:19][CH2:18][N:13]1[CH:17]=[CH:16][N:15]=[CH:14]1)=[O:4]

Komponenten

4

Edukt 2

HCID 8359Isatoic AnhydrideHCID 787361H-Imidazole-1-propanamine

Produkt 1

HCID 27983352-amino-N-(3-imidazol-1-ylpropyl)benzamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

A mixture of 2.93 g of isatoic anhydride, 2.50 g of 1H-imidazol-1-propanamine and 30 ml of toluene was heated at 90° C. for 45 minutes and cooled. The toluene layer was decanted and the residue was dissolved in methylene chloride, washed with dilute sodium hydroxide solution, water and dried over magnesium sulfate. The organic layer was concentrated to obtain the desired product, mp 107°-110° C.

Aufarbeitung

  1. temperaturecooled
  2. customThe toluene layer was decanted
  3. dissolutionthe residue was dissolved in methylene chloride
  4. washwashed with dilute sodium hydroxide solution, water
  5. dry with materialdried over magnesium sulfate
  6. concentrationThe organic layer was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-59cb4076b120478b94579999b94af08d
Quelldatensatz
uspto-grants-1987_07
Patentnummer
US04680293

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