HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-(2-Naphthyloxy)-8-chlorooctane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 2-Naphthol | HCID 8663 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 8-Chlorooctyl 4-methylbenzene-1-sulfonate | HCID 13957272 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | 1-(2-Naphthyloxy)-8-chlorooctane | HCID 13520539 | — |
Reaction Steps
A mixture of 17.5 g 2-naphthol, 32.0 g of 1-chloro-8-(p-toluenesulphonyloxy)octane, 32.0 g of anhydrous potassium carbonate and 200 ml of DMF was stirred at 60° for 4 hours. Water and ether were then added, the ethereal solution was separated, and washed with water and dilute aqueous potassium hydroxide, then dried and evaporated. The residue was chromatographed on silica gel, eluting with 3:2 hexane: dichloromethane, to afford the title compound as a solid, mp 35°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04680300 |
| Source dataset | uspto-grants-1987_07 |
| ORD ID | ord-32f52dab365044f99921d7d1dfd0cd84 |
| Source note | uspto-grants-1987_07 |