HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2118684Generated: October 31, 2026
Water → 2-n-Butyl-3,5-dihydro-5-phenyl-furo [3,2-c][1,8]naphthyridin-4(2H)-one
https://huagongshe.com/reaction/2118684
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 4-hydroxy-3-(2-hydroxyhexyl)-1-phenyl-1,8-naphthyridin-2(1H)-one | HCID 54717820 | — |
| Solvent | Hydrogen Bromide | HCID 260 | — |
| Product | 2-n-Butyl-3,5-dihydro-5-phenyl-furo [3,2-c][1,8]naphthyridin-4(2H)-one | HCID 13934587 | — |
Reaction Steps
A solution of 4-hydroxy-3-(2-hydroxyhexyl)-1-phenyl-1,8-naphthyridin-2(1H)-one (2g.) in 47% HBr was stirred in an atmosphere of nitrogen and heated to 80° C. for 41/2 hrs. after which time it was cooled and poured into water. The precipitate was filtered off, washed with water, dried in air, recrystallized from ethanol/charcoal to yield the product m.p. 179°-180° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04680297 |
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| Source dataset | uspto-grants-1987_07 |
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| ORD ID | ord-b0e9dd13a0bc4bd0b618966b6458f491 |
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| Source note | uspto-grants-1987_07 |
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