Water → HCID 13934588, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 4-hydroxy-3-(2-hydroxypropyl)-1-phenyl-1,8-naphthyridin-2(1H)-one (8.9 g; 0.03 mole) in 47% HBr (90 ml.) was stirred in an atmosphere of nitrogen. The solution was heated to 90° C. for 41/2 hrs. then was allowed to cool, poured into water and was adjusted to pH 4.5 with sodium acetate. The product was filtered off, washed with water, dried in air and recrystallized from CHCl3 /isopropanol to yield the product, m.p. 223°-224° C.

Provenance & Evidence