Sodium Iodide → 5-(3,4-Dichlorophenyl)-3,5-dihydro-2-methyl-furo[3,2-c][1,8]naphthyridin-4(2H)-one

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Reaction Steps

To a solution of 9-(3,4-dichlorophenyl)-3,9-dihydro-2-methyl-furo[2,3-b][1,8]naphthyridin-4(2H)-one (125 mg.) (prepared as in example 2) in dimethylacetamide (20 ml.) in an atmosphere of nitrogen was added sodium iodide (250 mg.). The solution was refluxed for 4 hrs., and it was poured over ice-water, filtered, dried and recrystallized from isopropanol to yield the desired product, m.p. 273°-274° C.

Provenance & Evidence