Thiophosgene → HCID 20192921, compound

Participants

Reaction Steps

To a mixture of 2 g of 6-amino-2-tert-butyl-5-[thiomorpholin-4-yl]benzothiazole and 2 g of anhydrous potassium carbonate in 150 ml of chloroform at 0° is added 0.6 ml of thiophosgene in 5 ml chloroform, under stirring. After 4 hours of stirring at ambient temperature the mixture is filtered. The filtrate is evaporated to a solid which is purified by silica gel column chromatography. The column is eluted with hexane/methylenechloride (1:1) to give 2-tert-butyl-6-isothiocyanato-5-[thiomorpholin-4-yl]benzothiazole, melting at 155°-159°.

Provenance & Evidence