1-Piperazinecarboxylic acid, ethyl ester → 2-Tert-butyl-5-[4-carbethoxypiperazin-1-yl]-6-nitrobenzothiazole

Participants

Reaction Steps

A mixture of 3.5 g of 2-tert.-butyl-5-chloro-6-nitrobenzothiazole, described in Example 5, and 5.8 g of N-carbethoxypiperazine is heated at 180° for 2 hours, cooled and poured into water. The solid is filtered, washed with water and crystallised from isopropyl alcohol to give 2-tert-butyl-5-[4-carbethoxypiperazin-1-yl]-6-nitrobenzothiazole, melting at 100°-102°.

Provenance & Evidence