Thiophosgene → HCID 20192945, compound

Participants

Reaction Steps

A mixture of 2 g of 6-amino-2-tert-butyl-5-[4-acetylpiperazin-1-yl]benzothiazole and 1.5 g of sodium bicarbonate in 150 ml of chloroform is cooled to 0° and 4 ml of thiophosgene is added dropwise and stirred at ambient temperature overnight. The solid is filtered off and the filtrate is evaporated under reduced pressure. The oil so obtained is applied on a silica gel column and eluted with 1% methanol in chloroform to yield 2-tert-butyl-6-isothiocyanato-5-[4-acetylpiperazin-1-yl]benzothiazole, melting at 100°-102°.

Provenance & Evidence