Piperazine → 2-Tert-butyl-6-nitro-5-[piperazin-1-yl]benzothiazole

Participants

Reaction Steps

A solution of 13.5 g of 2-tert-butyl-5-chloro-6-nitrobenzothiazole described in Example 5, and 40 g of anhydrous piperazine in 100 ml of dimethylsulphoxide is heated at 140° for 2 hours, cooled and poured into ice-water. The yellow solid is filtered, washed with water and dried at 80° to yield 2-tert-butyl-6-nitro-5-[piperazin-1-yl]benzothiazole, melting at 144°-146°.

Provenance & Evidence