Thiophosgene → HCID 20192957, compound

Participants

Reaction Steps

To a cooled mixture of 1.5 g of 6-amino-2-tert-butyl-5-[3-methylpiperidin-1-yl]benzothiazole and 1.5 g of potassium bicarbonate in 50 ml of chloroform is added dropwise 0.6 g of thiophosgene in 5 ml of chloroform under stirring. The stirring is continued for 30 minutes maintaining the temperature at 0°-2°. The solid is filtered and the filtrate is evaporated. The residue thus obtained is dissolved in chloroform and filtered through a silica gel column. The filtrate is evaporated to give 2-tert-butyl-6-isothiocyanato-5-[3-methylpiperidin-1-yl]benzothiazole, melting at 47°-52°.

Provenance & Evidence