HCID 20192943, compound → HCID 20192941, compound

HRID 2118759Notes

Reaction equation

HRID 2118759 reaction equation
[C:1]([C:5]1[S:6][C:7]2[CH:13]=[C:12]([N+:14]([O-])=O)[C:11]([N:17]3[CH2:22][CH2:21][CH2:20][CH:19]([CH3:23])[CH2:18]3)=[CH:10][C:8]=2[N:9]=1)([CH3:4])([CH3:3])[CH3:2]>CO.[Ni]>[NH2:14][C:12]1[C:11]([N:17]2[CH2:22][CH2:21][CH2:20][CH:19]([CH3:23])[CH2:18]2)=[CH:10][C:8]2[N:9]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[S:6][C:7]=2[CH:13]=1

Participants

4

Reactant 1

HCID 20192943HCID 20192943, compound

Product 1

HCID 20192941HCID 20192941, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

A solution of 1.7 g of 2-tert-butyl-5-[3-methylpiperidin-1-yl]-6-nitrobenzothiazole in 50 ml of methanol is hydrogenated in presence of 0.5 g of raney nickel at room temperature. After removing the catalyst the solution is concentrated and the solid filtered to give 6-amino-2-tert-butyl-5-[3-methylpiperidin-1-yl]benzothiazole melting at 108°-112°.

Workup

  1. customAfter removing the catalyst the solution
  2. concentrationis concentrated
  3. filtrationthe solid filtered

Sources & evidence

ORD record
ord-4aae0171e38141739f185c6e391a6b6b
Source dataset
uspto-grants-1987_07
Patent number
US04680301

Reaction notes

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