HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Tert-butyl-5-(4-methylpiperidin-1-yl)-6-nitrobenzothiazole → 6-Amino-2-tert-butyl-5-(4-methylpiperidin-1-yl)benzothiazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Tert-butyl-5-(4-methylpiperidin-1-yl)-6-nitrobenzothiazole | HCID 19794189 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-Amino-2-tert-butyl-5-(4-methylpiperidin-1-yl)benzothiazole | HCID 19794186 | — |
Reaction Steps
A solution of 15.2 g of 2-tert-butyl-5-[4-methylpiperidin-1-yl]-6-nitrobenzothiazole in 600 ml of methanol is hydrogenated in presence of 6.5 g of raney nickel at room temperature. After removing the catalyst the solution is concentrated and the solid filtered to give 6-amino-2-tert-butyl-5-[4-methylpiperidin-1-yl]benzothiazole melting at 146°-148°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04680301 |
| Source dataset | uspto-grants-1987_07 |
| ORD ID | ord-0c52bcae42524bf7a8e399ce69974129 |
| Source note | uspto-grants-1987_07 |