HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thionyl Chloride → 2-(4-Fluorophenyl)-3-methyl-butyryl chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | 2-(4-Fluorophenyl)-3-methylbutanoic acid | HCID 9800518 | — |
| Solvent | Benzene | HCID 241 | — |
| Product | 2-(4-Fluorophenyl)-3-methyl-butyryl chloride | HCID 22908416 | — |
Reaction Steps
50 g of 2-(p-fluorophenyl)-3-methylbutyric acid were dissolved in 200 ml of benzene and treated with 54.2 g of thionyl chloride. The mixture was stirred at 60° for 45 minutes and subsequently heated to reflux for 2 hours. After evaporation of the solvent the residue was distilled, whereby 2-(4-fluorophenyl)-3-methyl-butyryl chloride, b.p. 70°/93 Pa, was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04680310 |
| Source dataset | uspto-grants-1987_07 |
| ORD ID | ord-0a67adca122643d8b28be94d1c76de1b |
| Source note | uspto-grants-1987_07 |