Acetic Anhydride → HCID 14543798, compound

HRID 2118778Notes

Reaction equation

HRID 2118778 reaction equation
[C:1]([O:4][CH:5]1[NH:8][C:7](=[O:9])[CH:6]1[CH2:10][CH2:11][CH3:12])(=[O:3])[CH3:2].[C:13](OC(=O)C)(=[O:15])[CH3:14]>N1C=CC=CC=1>[C:13]([N:8]1[CH:5]([O:4][C:1](=[O:3])[CH3:2])[CH:6]([CH2:10][CH2:11][CH3:12])[C:7]1=[O:9])(=[O:15])[CH3:14]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 14543786HCID 14543786, compound

Product 1

HCID 14543798HCID 14543798, compoundYield 23%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

A mixture of 56 mg (0.33 mM) 4-acetoxy-3-propylazetidin-2-one, 1 ml acetic anhydride and 1 ml pyridine was stirred at 100° in a sealed tube for 24 hours. After concentrating in vacuo the residue was chromatographed on silica gel in hexane/ethyl acetate, to yield 16 mg (23%) 1-acetyl-4-acetoxy-3-n-propyl-azetidine-2-one.

Workup

  1. concentrationAfter concentrating in vacuo the residue
  2. customwas chromatographed on silica gel in hexane/ethyl acetate

Sources & evidence

ORD record
ord-8986255b872b4d0fa95be56f23064912
Source dataset
uspto-grants-1987_07
Patent number
US04680391

Reaction notes

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