HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Anhydride → 1-Acetyl-4-(methylthio)azetidin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | 4-(Methylsulfanyl)azetidin-2-one | HCID 12677248 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | 1-Acetyl-4-(methylthio)azetidin-2-one | HCID 14543785 | 78% |
Reaction Steps
A mixture of 300 mg (2.6 mM) 4-methylthioazetidin-2-one, 10 ml acetic anhydride and 10 ml pyridine was stirred at 100° in a sealed tube 24 hours. After concentrating in vacuo, the residue was chromatographed on silica gel in hexane/ethyl acetate to yield 324 mg (78%) of 1-acetyl-4-methylthioazetidine-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04680391 |
| Source dataset | uspto-grants-1987_07 |
| ORD ID | ord-18a69e3e94d84657a2009dc57446e3cd |
| Source note | uspto-grants-1987_07 |