反应详情

2.5 g of cyclopropylamine are added dropwise to a solution of 11 g of 2-(2,4-dichloro-benzoyl)-3-methoxyacrylonitrile in 40 ml of ethanol, while cooling with ice and stirring. The mixture is stirred at room temperature for 25 minutes and then heated at the boiling point for 15 minutes. The solvent is removed in vacuo and the residue is recrystallized from ethanol/light petrol. 10.5 g of 2-(2,4-dichloro-benzoyl)-3-cyclopropylaminoacrylonitrile of melting point 93°-94° C. are obtained.

1. temperaturewhile cooling with ice
2. stirringThe mixture is stirred at room temperature for 25 minutes
3. temperatureheated at the boiling point for 15 minutes
4. customThe solvent is removed in vacuo
5. customthe residue is recrystallized from ethanol/light petrol