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Iodine → 7-Iodo-4-ethylisoindolinone
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodine | HCID 807 | — |
| 反応物 | Potassium Iodide | HCID 4875 | — |
| 反応物 | Nitric acid, 1,1-dimethylethyl ester | HCID 164756 | — |
| 反応物 | 7-Amino-4-ethylisoindolinone | HCID 68490969 | — |
| 触媒 | Copper iodide | HCID 83717 | — |
| 溶媒 | Acetonitrile | HCID 6342 | — |
| 生成物 | 7-Iodo-4-ethylisoindolinone | HCID 68491946 | 50% |
反応手順
In a similar manner to Step 4 of Example 140, 7-amino-4-ethylisoindolinone (46.0 mg, 0.260 mmol) was dissolved in acetonitrile (6.2 mL), and the solution was treated with potassium iodide (69.1 mg, 0.416 mmol), copper iodide (79.2 mg, 0.416 mmol), iodine (106 mg, 0.416 mmol) and tert-butyl nitrate (0.139 mL, 1.17 mmol), followed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=5/1) to obtain 7-iodo-4-ethylisoindolinone (37.1 mg, yield 50%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07745641B2 |
| 出典データセット | uspto-grants-2010_06 |
| ORD ID | ord-984a387cb3f94937a9bcf4b5064c2b1c |
| 出典メモ | uspto-grants-2010_06 |