HCID 13689547, compound → HCID 13689546, compound

HRID 2118822Notes

Reaction equation

HRID 2118822 reaction equation
C([O:4][C:5]1[CH:6]=[C:7]([CH:19]=[CH:20][C:21]=1[O:22]C(=O)C)[C:8]([NH:10][NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])=[O:9])(=O)C>CO.O>[OH:4][C:5]1[CH:6]=[C:7]([CH:19]=[CH:20][C:21]=1[OH:22])[C:8]([NH:10][NH:11][C:12]([O:14][C:15]([CH3:17])([CH3:18])[CH3:16])=[O:13])=[O:9]

Participants

4

Reactant 1

HCID 13689547HCID 13689547, compound

Product 1

HCID 13689546HCID 13689546, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

1-[3,4-bis(Acetyloxy)benzoyl]-2-[(t-butyloxy)carbonyl]hydrazine (2.6 g) was dissolved in 50 ml of methanol and 5 ml of water. At 0° C., ammonia (gas) was bubbled into the solution for 10 minutes. After standing overnight in a refrigerator, the solution was evaporated, and to the remaining oil, 10 ml of dichloromethane was added. This yielded 1.5 g of the title compound, melting point 148° C.

Workup

  1. customAt 0° C., ammonia (gas) was bubbled into the solution for 10 minutes
  2. customthe solution was evaporated
  3. additionto the remaining oil, 10 ml of dichloromethane was added

Sources & evidence

ORD record
ord-72239aff0d47436bac7980c61fb8f05d
Source dataset
uspto-grants-1987_07
Patent number
US04680409

Reaction notes

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