HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → HCID 12831967, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 6-Bromo-8-chloro-3,4-dihydro-2H-1-benzopyran-4-one | HCID 12831966 | — |
| Catalyst | Zinc | HCID 23994 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 12831967 | HCID 12831967 | 50.3% |
Reaction Steps
To the amalgam of zinc--prepared from 1280 g (19.7 gram-atoms) of zinc, 128 g (5.4×10-1M) of mercurous chloride, 64 cm3 of concentrated hydrochloric acid and 1900 cm3 of water--are added, in order, 1000 cm3 water, 1500 cm3 of concentrated hydrochloric acid, 3500 cm3 of toluene and 640 g (2.45M) of 6-bromo-8-chloro-4-chromanone (III2). The mixture is refluxed for 1 hour and, after cooling and decantation, it is extracted with ether and washed in water up to neutrality. 305 g (yield=50%) of expected product are thus isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04680411 |
| Source dataset | uspto-grants-1987_07 |
| ORD ID | ord-bc9ab2f54c534505beb1dab20e8bf18c |
| Source note | uspto-grants-1987_07 |