HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2118825Generated: October 26, 2026
Diethyl Ether → 8-Methoxychromane-6-carbaldehyde
https://huagongshe.com/reaction/2118825
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Bromo-methoxy-chroman | HCID 20193557 | — |
| Reactant | Butyllithium | HCID 178418339 | — |
| Solvent | Diisopropyl Ether | HCID 7914 | — |
| Product | 8-Methoxychromane-6-carbaldehyde | HCID 12831983 | 51% |
Reaction Steps
The procedure is as according to the method described for preparation III, but maintaining the temperature at -50° C. From 186 g (7.7×10-1M) of bromo-methoxy-chroman Ib2 in 500 cm3 of anhydrous ether and 7.7×10-1M of n-butyllithium in 650 cm3 of anhydrous ether, and after addition of 78 g (1.1M) of N,N-dimethylformamide in 200 cm3 of anhydrous ether and recrystallisation in isopropyl ether, 75 g (yield=51%) of expected compound are isolated.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04680411 |
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| Source dataset | uspto-grants-1987_07 |
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| ORD ID | ord-7bd04b9411524ac1a93fde216abe0d4a |
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| Source note | uspto-grants-1987_07 |
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