HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 12718468, compound → 1-carboxymethyl-3-(S)-[(1-ethoxycarbonyl-3-(3-indolyl)propyl)amino]perhydroazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 12718468 | HCID 12718468 | — |
| Reactant | [(3S)-3-Amino-2-oxoazepan-1-yl]acetic acid | HCID 13749497 | — |
| Product | 1-carboxymethyl-3-(S)-[(1-ethoxycarbonyl-3-(3-indolyl)propyl)amino]perhydroazepin-2-one | HCID 18605795 | — |
Reaction Steps
In the same manner react the 3-(S)-amino-1-carboxymethylperhydroazepin-2-one with ethyl 4-(3-indolyl)-2-oxobutyrate to obtain 1-carboxymethyl-3-(S)-[(1-ethoxycarbonyl-3-(3-indolyl)propyl)amino]perhydroazepin-2-one. Standard alkaline hydrolysis (as in Example 3) of this material yields 1-carboxymethyl-3-(s)-[(1-carboxy-3-(3-indolyl)propyl)amino]perhydroazepin-2-one. Alternatively, esterification in HCl-ethanol affords 1-ethoxycarbonylmethyl-3-(S)-1-(1-ethoxycarbonyl-3-(3-indolyl)lpropyl)amino]-perhydroazepin-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04680392 |
| Source dataset | uspto-grants-1987_07 |
| ORD ID | ord-f08e742fe0a948bcb4f72e9ecbf91058 |
| Source note | uspto-grants-1987_07 |