HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 1-Carboxymethyl-3-(S)-[(1-carboxy-2-phenylethyl)amino]perhydroazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | [(3S)-3-Amino-2-oxoazepan-1-yl]acetic acid | HCID 13749497 | — |
| Reactant | Sodium phenylpyruvate monohydrate | HCID 23666336 | — |
| Solvent | Water | HCID 962 | — |
| Product | 1-Carboxymethyl-3-(S)-[(1-carboxy-2-phenylethyl)amino]perhydroazepin-2-one | HCID 18605789 | — |
Reaction Steps
Prepare an aqueous solution of 500 mg 3-(S)-amino-1-carboxymethylperhydroazepin-2-one in 5 ml water. Adjust the pH to 6 with 1N sodium hydroxide solution and add 15 ml water. React this amine with 2.24 g sodium phenylpyruvate monohydrate and 400 mg sodium cyanoborohydride as described in Example 1. Purify 370 mg of the crude product on an LH-20 column and isoalte 240 mg of 1-carboxymethyl-3-(S)-[(1-carboxy-2-phenylethyl)amino]perhydroazepin-2-one.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04680392 |
| Source dataset | uspto-grants-1987_07 |
| ORD ID | ord-d20c97ce46054334b72e1f9a038f0f2e |
| Source note | uspto-grants-1987_07 |