Benzyl Alcohol → HCID 20193448, compound

Participants

Reaction Steps

Reaction of the major isomer of 3-amino-1-t-butoxymethyl-7-methylperhydroazepin-2-one with benzyl alcohol and thionyl chloride yields 3-amino-1-benzyloxymethyl-7-methylperhydroazepin-2-one hydrochloride, which after treatment with base, yields the free amino ester. Reaction of this amino ester as described in Example 37 affords the products of Formula I (R3, R5, R6 =H; CH3 ; R=OH) listed in Table IV.

Provenance & Evidence