Triethylamine → N-[2-(2-chloroethoxy)-phenylsulfonyl]-N'-methylurea

Participants

Reaction Steps

5.9 g of triethylamine is added dropwise to a suspension of 11.0 g of 2-(2-cloroethoxy)-phenylsulfonamide, 50 ml of methylene chloride and 3.3 g of methyl isocyanate within 10 minutes at a temperature of 20°-25° C. The resulting clear solution is stirred for a further hour at room temperature and evaporated to dryness. The residue is solved in 5% aqueous sodium carbonate. After acidification of this solution with 10% hydrochloric acid 12.5 g of N-[2-(2-chloroethoxy)-phenylsulfonyl]-N'-methylurea precipitate therefrom, m.p. 218°-222° C.

Provenance & Evidence