Ammonia → 4-Amino-2,3,5,6-tetrafluoropyridine

HRID 2118947Notes

Reaction equation

[F:1][C:2]1[N:7]=[C:6]([F:8])[C:5]([F:9])=[C:4](F)[C:3]=1[F:11].[NH3:12]>>[NH2:12][C:4]1[C:3]([F:11])=[C:2]([F:1])[N:7]=[C:6]([F:8])[C:5]=1[F:9]

Participants

Reactant 2

HCID 222Ammonia

HCID 69690Pentafluoropyridine

Product 1

HCID 12709114-Amino-2,3,5,6-tetrafluoropyridine

Procedure

A mixture of 20.0 g (118 mmol) of pentafluoropyridine (Aldrich Chemical Company, Milwaukee, Wis., USA) and 40 ml of concentrated aqueous ammonia was heated on a steam bath for two hours in a sealed stainles steel reaction vessel. The vessel and contents were cooled to room temperature and the resulting suspension suspension was partitioned between water and diethyl ether.

Workup

customthe resulting suspension suspension was partitioned between water and diethyl ether

Sources & evidence

ORD record: ord-2688f0a921af477395974022799b7504
Source dataset: uspto-grants-1987_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04681873

Reaction notes

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