反应详情

The starting compound is prepared as follows. A solution of 2-amino-4-methylpyrimidine (21.8 g) and p-nitrobenzaldehyde (30.2 g) in formic acid (45 ml) is refluxed (24 hours). After cooling, the reaction mixture is poured into water (1 liter), and the aqueous mixture is neutralized with a 5N sodium hydroxide solution. The crude product is extracted with chloroform, and the extract is dried over sodium sulfate and concentrated to dryness. The crude product is purified on a silica gel column to give 4-[2-(p-nitrophenyl)ethenyl]-2-aminopyrimidine (27.8 g), m.p. 214°-216° C., which is used for the next step without purification.

1. customThe starting compound is prepared
2. temperatureAfter cooling
3. extractionThe crude product is extracted with chloroform
4. dry with materialthe extract is dried over sodium sulfate
5. concentrationconcentrated to dryness
6. customThe crude product is purified on a silica gel column