HCID 131715224, compound → HCID 53665640, compound

Participants

Reaction Steps

To a solution of the phenylmethyl ester product of part (i) (505 mg., 0.69 mmole) in 40 ml. of absolute ethanol is added approximately 70 mg. of 10% palladium on charcoal. The resulting mixture is stirred under hydrogen for approximately 2.5 hours at which time Tlc analysis shows no starting material remaining. The mixture is filtered and concentrated at reduced pressure to give a pale gray foam which is dried under vacuum overnight to give 430 mg. of material. In order to remove additional palladium/charcoal, this material is dissolved in ethanol, millipore filtered, and concentrated at reduced pressure. The residue is dissolved in tetrahydrofuran, precipitated with ether to give a white solid, and dried overnight under vacuum to give (cis)-4-[3-[6-(aminosulfonyl)-7-chloro-1,2,3,4-tetrahydro-4-oxo-2-quinazolinyl]phenoxy]-1-[[(3-ethoxy-3-oxopropyl)ethylamino]carbonyl]-L-proline.

Provenance & Evidence