2-Bromopyridine → 2-Pyridinamine, N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-

Participants

Reaction Steps

3-[3-(Piperidinomethyl)phenoxy]propylamine (20 g) and 2-bromopyridine (12.64 g) were stirred at 125° C. for 31/2 days. The cooled reaction mixture was subjected to column chromatography on silica ((chloroform:methanol 10:1) to afford the title compound as an oil. This was treated with maleic acid in ethanol to give, on addition of diethyl ether, as a white solid 2-[3-[3-(piperidinomethyl)phenoxy]propylamino]pyridine dimaleate (11.40 g), m.p. 116°-167° C. (recrystallised from isopropanol).

Provenance & Evidence