2-Bromothiazole → HCID 14022497, compound

Participants

Reaction Steps

3-[3-(Piperidinomethyl)phenoxy]propylamine (7.45 g) and 2-bromothiazole (2.46 g) in pyridine (25 ml) were stirred under reflux for 20 hours. The reaction mixture was cooled, evaporated and partitioned between chloroform and water. The chloroform layer was evaporated and subjected to medium pressure column chromatography on silica (chloroform:methanol 19:1) to give the title compound as an oil. This was converted to 2-[3-[3(piperidinomethyl)phenoxy]propylamino]thiazole dihydrochloride, m.p. 192.5°-193.5° C. (recrystallised from isopropanol-ethyl acetate).

Provenance & Evidence