HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methyl-2-(methylsulfanyl)-1H-benzimidazole → HCID 23035476, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methyl-2-(methylsulfanyl)-1H-benzimidazole | HCID 415665 | — |
| Reactant | 3-(3-(Piperidin-1-ylmethyl)phenoxy)propan-1-amine | HCID 10220561 | — |
| Product | HCID 23035476 | HCID 23035476 | — |
Reaction Steps
3-[3-(Piperidinomethyl)phenoxy]propylamine (2.41 g) and 1-methyl-2-methylthiobenzimidazole (1.57 g) were fused at 150° C. for 6 hours. The cooled residue was subjected to column chromatography on silica (chloroform:methanol 19:1) to give the title compound as an oil. This was treated with maleic acid to give 2-[3-[3-(piperidinomethyl)phenoxy]propylamino]-1-methylbenzimidazole dimaleate (0.87 g), m.p. 153°-154° C. (recrystallised from isopropanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04681883 |
| Source dataset | uspto-grants-1987_07 |
| ORD ID | ord-cd25277892e94a4e9c595c52781d81e1 |
| Source note | uspto-grants-1987_07 |